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怀济森博士

时间:2022-10-14 09:13   作者: 阅读:

曾任德国美因茨大学医院分子医学课题组长,德国国家研究基金重点资助项目两项主持人。在武汉大学博士后期间,曾获法国梅里埃奖章和瑞典皇家研究基金。截止目前已在包括PNAS,Dev Cell,EMBO Mol Med 以及CDD在内的核心期刊发表论文多篇。目前任 Frontier in Neurology 和 Current Alzheimer Research客座编辑, Biochimie和The International Journal of Molecular Science特邀审稿人。

研究方向:肌萎缩侧索硬化;阿尔茨海默氏病

代表论文:

1.Structural Properties and Interaction Partners of Familial ALS-Associated SOD1 Mutants. Huai J, Zhang Z. Front Neurol. 2019 May 21;10:527. doi: 10.3389/fneur.2019.00527. eCollection 2019.

2.PRG-1 Regulates Synaptic Plasticity via Intracellular PP2A/β1-Integrin Signaling. Liu X, Huai J (corresponding), Endle H, Schlüter L, Fan W, Li Y, Richers S, Yurugi H, Rajalingam K, Ji H, Cheng H, Rister B, Horta G, Baumgart J, Berger H, Laube G, Schmitt U, Schmeisser MJ, Boeckers TM, Tenzer S, Vlachos A, Deller T, Nitsch R, Vogt J. Dev Cell. 2016 Aug 8;38(3):275-90. doi: 10.1016/j.devcel.2016.06.019. Epub 2016 Jul 21.

3.Molecular cause and functional impact of altered synaptic lipid signaling due to a prg-1 gene SNP. Vogt J, Yang JW, Mobascher A, Cheng J, Li Y, Liu X, Baumgart J, Thalman C, Kirischuk S, Unichenko P, Horta G, Radyushkin K, Stroh A, Richers S, Sahragard N, Distler U, Tenzer S, Qiao L, Lieb K, Tüscher O, Binder H, Ferreiros N, Tegeder I, Morris AJ, Gropa S, Nürnberg P, Toliat MR, Winterer G, Luhmann HJ, Huai J (Equal contribution to corresponding), Nitsch R. EMBO Mol Med. 2016 Jan 1;8(1):25-38. doi: 10.15252/emmm.201505677.

4.TNFα-induced lysosomal membrane permeability is downstream of MOMP and triggered by caspase-mediated NDUFS1 cleavage and ROS formation. Huai J, Vögtle FN, Jöckel L, Li Y, Kiefer T, Ricci JE, Borner C. J Cell Sci. 2013 Sep 1;126(Pt 17):4015-25. doi: 10.1242/jcs.129999. Epub 2013 Jun 20.

5.Activation of cellular death programs associated with immunosenescence-like phenotype in TPPII knockout mice. Huai J, Firat E, Nil A, Million D, Gaedicke S, Kanzler B, Freudenberg M, van Endert P, Kohler G, Pahl HL, Aichele P, Eichmann K, Niedermann. Proc Natl Acad Sci U S A. 2008 Apr 1;105(13):5177-82. doi: 10.1073/pnas.0801413105. Epub 2008 Mar 24


招生方向:生物学 神经生物学

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