留学德国获得神经生物学博士学位并在美国NIH从事博士后研究。课题组已承担10多项国科基金并在PNAS和Science Signaling等知名期刊发表科研论文30余篇。兼职中国病理生理学会和中国科协科创。

研究方向：蛋白质棕榈酰化修饰的分子和生理功能

蛋白棕榈酰化修饰是蛋白质翻译后修饰的一种，在生命活动过程中发挥着重要的功能。研究表明，S-棕榈酰化修饰是动态可逆的脂质修饰，广泛参与了细胞内多样的调节作用。实验室的研究重点是在生命科学的多个领域研究蛋白质棕榈酰化修饰的分子和生理功能，使用ZDHHCs和PPTs的基因敲除小鼠模型来探究这些修饰酶的作用。此外，我们还利用遗传性疾病小鼠模型来了解神经退行性疾病、肿瘤发生和男性不育等病症的病理机制，最终的目标是揭示这些机制，并发现潜在的治疗策略，以干预并阻止疾病的进展。

代表成果：

1.Liu, H., Yan, P., Wu, C., Rao, M., Zhu, J., Lv, L., Li, W., Liang, Y., Qi, S., Lu, K., and Kong, E. # (2023) Palmitoylated Sept8-204 modulates learning and anxiety by regulating filopodia arborization and actin dynamics. Science Signaling 16, eadi8645.

2.Tang, D., Zheng, K., Zhu, J., Jin, X., Bao, H., Jiang, L., Li, H., Wang, Y., Lu, Y., Liu, J., Liu, H., Tang, C., Feng, S., Dong, X., Xu, L., Yin, Y., Dang, S., Wei, X., Ren, H., Dong, B., Dai, L., Cheng, W., Wan, M., Li, Z., Chen, J., Li, H., Kong, E.#, Wang, K. #, Lu, K. #, and Qi, S. # (2023) ALS-linked C9orf72-SMCR8 complex is a negative regulator of primary ciliogenesis. Proceedings of the National Academy of Sciences of the United States of America 120, e2220496120.

3.Zhou B, Wang Y, Zhang L, Shi X, Kong H, Zhang M, Liu Y, Shao X, Liu Z, Song H, Li W, Gao X, Chang Y, Dou C, Guo W, Zhang S, Kang X, Gao J, Liang Y, Zheng J, Kong E. #  (2022). The palmitoylation of AEG-1 dynamically modulates the progression of hepatocellular carcinoma. Theranostics. 12(16):6898-6914.

4.Yan, P., H. Liu, T. Zhou, P. Sun, Y. Wang, X. Wang, L. Zhang, T. Wang, J. Dong, J. Zhu, L. Lv, W. Li, S. Qi, Y. Liang and E. Kong# (2022). "Crosstalk of Synapsin1 palmitoylation and phosphorylation controls the dynamicity of synaptic vesicles in neurons." Cell Death & Disease 13(9): 786.

5.Yuan, W., L. Lu, M. Rao, Y. Huang, C. E. Liu, S. Liu, Y. Zhao, H. Liu, J. Zhu, T. Chao, C. Wu, J. Ren, L. Lv, W. Li, S. Qi, Y. Liang, S. Yue, J. Gao, Z. Zhang and E. Kong# (2021). "GFAP hyperpalmitoylation exacerbates astrogliosis and neurodegenerative pathology in PPT1-deficient mice." Proceedings of the National Academy of Sciences of the United States of America 118(13).

 招生方向:生物化学与分子生物学;生物技术与工程

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