郭春磊,南开大学理学博士,副教授,硕士生导师,2017年至今就职于ylzzcom永利总站线路检测医学检验学院。目前的研究方向为肿瘤免疫,主要从事肿瘤干细胞与肿瘤微环境之间相互调控的机制研究。累计主持国家自然科学基金1项,河南省高校重点科研项目1项,在Theranostics、Front Bioeng Biotechnol、Int J Pharm等杂志发表SCI论文7篇。
【研究工作经历】
2017.07-2021.12 ylzzcom永利总站线路检测医学检验学院 讲师
2022.01-至今 ylzzcom永利总站线路检测医学检验学院 副教授
【承担及完成课题】
1. FBF1促进乳腺癌细胞干性和侵袭转移的机制研究,国家自然科学基金青年项目,2019.01--2021.12,主持,21万元。
2. FBF1调控肿瘤干细胞特性促进乳腺癌血管新生的机制研究,河南省高等学校重点科研项目,2019.01--2020.12,主持,5万元。
3.炎症相关基因调控肿瘤细胞干性和转移的机制研究,博士启动基金,主持,50万元。
【代表性论著】(#为第一作者,*为通讯作者)
1.Guo Chunlei#, Chen Yanan#, Gao Wenjuan, Chang Antao, Ye Yujie, Shen Wenzhi, Luo Yunping, Yang Shengyong, Sun Peiqing, Xiang Rong*, and Li Na*. Liposomal Nanoparticles Carrying anti-IL6R Antibody to the Tumour Microenvironment Inhibit Metastasis in Two Molecular Subtypes of Breast Cancer Mouse Models. Theranostics. 2017 ;7(3):775-788.
2.Guo Chunlei#, Li Shuang#, Liang Ang, Cui Mengchao, Lou Yunwei and Wang Hui*. PPA1 Promotes Breast Cancer Proliferation and Metastasis Through PI3K/AKT/GSK3β Signaling Pathway. Frontiers in Cell and Developmental Biology. 2021;9:730558.
3.Liu Hui#,Guo Chunlei#,Shang Yuhong, Zeng Lin, Jia Haixue, and Wang Zhongyan*. A Supramolecular Nanoparticle of Pemetrexed Improves the Anti-Tumor Effect by Inhibiting Mitochondrial Energy Metabolism. Front Bioeng Biotechnol. 2021 ;9:804747.
4.Hou Jie,Guo Chunlei, Shi Yuzhi, Liu Ergang, Dong Weibing, Yu Bo, Liu Shiyuan, Gong Junbo*. A novel high drug loading mussel-inspired polydopamine hybrid nanoparticle as a pH-sensitive vehicle for drug delivery. Int J Pharm. 2017 ;533(1):73-83.
5. Zhen Ye,Chunlei Guo, Wenzhi Shen, Shuangtao Zhao, Na Luo, Rongrong Wang, Xiaohe Luo, Haiying Niu, Dehong Luo, Shan Jiang, Xiaoyue Tan*, Rong Xiang*. Clinicopathologic significance of legumain overexpression in cancer: a systematic review and meta-analysis. Sci Rep. 2015 ;5:16599.
6. Liu Bowen, Cao Jinling, Wang Xiangyun,Guo Chunlei, Liu Yunxia and Wang Tianjiao. Deciphering the tRNA-derived small RNAs: origin, development, and future. Cell Death Dis. 2021 ;13(1):24.
7. Liu Hui, Zeng Lin, Yang Yang,Guo Chunleiand Wang Hui*. Bcl-3: A Double-Edged Sword in Immune Cells and Inflammation. Front Immunol. 2022 ;13: 847699.