刘慧，1991.12-，博士、讲师、硕士生导师。2018年于南开大学取得博士学位，师从免疫学家尹芝南教授。目前研究方向为代谢免疫和肿瘤疫苗，主要从事T细胞代谢与免疫功能的研究、小分子药物对肿瘤的靶向治疗研究及肿瘤疫苗的制备及免疫相关研究。
邮箱：hsdliuhui@163.com
【受教育经历】
2013.09 ~ 2018.07 南开大学生命科学学院 生物化学与分子生物学 硕博连读
2009.09 ~ 2013.07 河南师范大学生命科学学院 生物科学 理学学士
【工作经历】
2018.07 ~至今 ylzzcom永利总站线路检测医学检验学院 临床免疫学教研室 讲师
【承担及完成国家级/省级课题】
1. Bcl-3通过mTORC1信号通路调节CD4+T细胞代谢及功能的机制研究，刘慧，国家自然科学基金，2020.01-2022.12.31，No. 81901590，21万元；
2. β葡聚糖包含铝佐剂作为新的抗原负载系统在乙肝疫苗当中的免疫作用机制的研究，刘慧，河南省教育厅，2020.01-2021.12.31，No. 20A310014，3万元；
【发表SCI论文】
[1] Hui Liu; Lin Zeng; Yang Yang; Chunlei Guo; Hui Wang; Bcl-3: A Double-Edged Sword in Immune Cells and Inflammation, Frontiers in Immunology, 2022 ;13:847699.
[2] Hui Liu; Chunlei Guo; Yuhong Shang; Lin Zeng; Haixue Jia; Zhongyan Wang; A Supramolecular Nanoparticle of Pemetrexed Improves the Anti-Tumor Effect by Inhibiting Mitochondrial Energy Metabolism, Frontiers in Bioengineering and Biotechnology,2021 ;9:804747.
[3] Liu H, Meng Z, Wang H, Zhang S, Huang Z, Geng X, Guo R, Wu Z, Hong Z. Robust Immune Responses Elicited by a Hybrid Adjuvant Based on β-Glucan Particles from Yeast for the Hepatitis B Vaccine. ACS Appl Bio Mater. 2021 ;4(4):3614-3622.
[4]Hui Liu,Zhenghu Jia, Chengmao Yang, Mei Song, Zhe Jing, Yapu Zhao, Liqing Zhao, Zhenzhou Wu, Dongsheng Wei, Zhinan Yin, Zhangyong Hong. Aluminum hydroxide colloid vaccine encapsulated in yeast shells with enhanced humoral and cellular immune responses.Biomaterials.2018; 167:32-43.
[5] Hui Liu,Mei Zhao, Jin Wang, Mingpei Pang, Zhenzhou Wu, Liqing Zhao, Zhinan Yin, Zhangyong Hong.Photodynamic therapy of tumors with pyropheophorbide a loaded polyethylene glycol–poly (lactic-co-glycolic acid) nanoparticles [J].International Journal of Nanomedicine,2016;11:4905-4918.
[6] Jin Wang, Qian Liu, Yuting Zhang, Huan Shi,Hui Liu,Wenjun Guo, Yanhong Ma, Weiqiang Huang Zhangyong Hong. Folic acid conjugated pyropheophorbidea as the photosensitizer tested for in vivo targeted photodynamic therapy.Journal of Pharmaceutical Sciences, 2017;106(6), 1482-1489.
[7] Guangchao Cao, Qian Wang, Jiyu Tong, Wanjun Huang, Dewei Ye, Yan He,
Zonghua Liu, Xin Tang, Hao Cheng, Qiong Wen, Dehai Li, Hau Tak Chau, Yiming Wen, Hui Zhong,Ziyu Meng,Hui Liu,Zhenzhou Wu, Liqing Zhao, Richard Flavell, Hongwei Zhou, Aimin Xu, Hengwen Yang, and Zhinan Yin. Long term consumption of caffeine-free high-sucrose cola beverages aggravates the pathogenesis of EAE in mice.Cell Discovery,2017 ;3:17020.
[8] Guangchao Cao, Qian Wang, Guangqiang Li,Ziyu Meng,Hui Liu,Jiyu Tong, Wanjun Huang, Zonghua Liu, Jun Wei, Hongbo Chi, Hengwen Yang, Liqing Zhao, Zhenzhou Wu, Jianlei Hao, Zhinan Yin. mTOR inhibition potentiates cytotoxicity of Vγ4 γδ T cells via up-regulating NKG2D and TNF-α [J].Journal of Leukocyte Biology,2016;100:1181-1189.
[9] Rong Luan, Hao Cheng, Lin Li,HuiLiu, Qiang Zhao,Zhenzhou Wu, Liqing Zhao, Zhinan Yin.Maternal Lipopolysaccharide Exposure Promotes Immunological Functional Changes in Adult Offspring CD4(+) T Cells.[J].American Journal of Reproductive Immunology,2015; 73(6):522.
